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期刊论文 13

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2020 1

2013 1

2010 7

2009 1

2006 1

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泥水盾构 5

砂卵石地层 4

CRD法 1

三角形自分解 1

压滤 1

厦门翔安海底隧道 1

同步注浆 1

地质三维模型 1

地震预测 1

多比例尖灭 1

大尺度地层内的分层运动 1

大断面 1

大直径 1

富水地层 1

富水砂卵石 1

带压换刀 1

施工技术 1

施工方法 1

沉降规律 1

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Influence of short chain ceramides and lipophilic penetration enhancers on the nano-structure of stratumcorneum model membranes studied using neutron diffraction

Annett SCHROETER, Tanja ENGELBRECHT, Reinhard H. H. NEUBERT

《化学科学与工程前沿（英文）》 2013年第7卷第1期页码 29-36 doi: 10.1007/s11705-013-1302-0

摘要： Oriented stratum corneum model lipid membranes were used to study the influence of the short chain ceramides (CER)[NP] and [AP] as well as the impact of the lipophilic penetration enhancer molecules oleic acid (OA) and isopropyl myristate (IPM) on the lipid nanostructure. The influence of the enhancer molecules were studied using specifically deuterated OA and IPM and neutron diffraction. H NMR spectroscopy was used to study the impact of the ceramides’ degree of order within the stratum corneum model lipid membranes. It was found that CER[NP] forms two very stable phases with high resistance against temperature increase. Phase B showed unusual hydration behavior as no water uptake of this phase was observed. The H NMR spectroscopic measurements showed that CER[NP] based ternary model system had a higher state of lamellar order in comparison to CER[AP] based lipid matrix. The studies confirmed that the short chain ceramides, particularly CER[NP], have a very high impact on the integrity of the Stratum corneum lipid bilayers. The penetration enhancer OA has not influenced the repeat distance of the model membrane based on CER[AP], and was not able to induce a phase separation in the investigated lipid matrix. However, a disorder and a fluidisation of the model membranes were observed when OA was incorporated. IPM showed the same effect but two phases (assigned as phase A and B) appeared, when IPM was used as penetration enhancer and incorporated into the model membrane. Furthermore, two arrangements of IPM were identified in phase A using deuterated IPM. A model of the nanostructure of the Stratum corneum lipid membranes is presented.

关键词： nano-structure of the stratum corneum ceramide penetration enhancer model membrane neutron diffraction ²H NMR spectroscopy

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Enhanced penetration strategies for transdermal delivery

Qiaofei Pan, Yinglin Yu, Dong Chen, Genlong Jiao, Xiaowen Liu

《化学科学与工程前沿（英文）》 2020年第14卷第3期页码 378-388 doi: 10.1007/s11705-019-1913-1

摘要： Transdermal delivery offers several advantages in drug distribution, including convenience, painless administration, avoidance of first-pass metabolism, and ease of termination. However, the natural protective barriers of the skin, such as the stratum corneum, the topmost layer of skin, limit the systemic absorption of external therapeutics via transdermal delivery. Therefore, extensive application of transdermal delivery in medical treatment has been limited. Over the past few years, many formulation strategies and physical technologies, therefore, have been developed to enhance transdermal delivery. This review summarizes various formulation strategies proposed for transdermal delivery and their application in medical treatment.

关键词： transdermal delivery stratum corneum enhanced penetration therapeutics

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piles in the pile-caisson composite structure under eccentric inclined loading considering different stratum

《结构与土木工程前沿（英文）》 doi: 10.1007/s11709-023-0957-y

摘要： A novel anchorage for long-span suspension bridges, called pile-caisson composite structures, was recently proposed by the authors in an attempt to reduce the construction period and costs. This study aims to investigate the displacement and force behavior of piles in a pile-caisson composite structure under eccentric inclined loading considering different stratum features. To this end, both 1g model tests and three-dimensional numerical simulations were performed. Two groups of 1g model tests were used to validate the finite-element (FE) method. Parametric studies were then performed to investigate the effects of groundwater level, burial depth of the pile-caisson composite structure, and distribution of soil layers on the performance of the pile-caisson composite structure. The numerical analyses indicated that the influence of the groundwater level on the stability of the caisson was much greater than that of the piles. In addition, increasing the burial depth of the pile-caisson composite structure can assist in reducing the displacements and improving the stability of the pile-caisson composite structure. In addition, the distribution of soil layers can significantly affect the stability of the pile-caisson composite structure, especially the soil layer around the caisson.

关键词： composite structure piles foundation suspension bridge 1g model test finite-element analysis

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Experimental study on the stratum applicability and mechanisms of bubble–slurry for earth pressure balance

《结构与土木工程前沿（英文）》页码 1387-1399 doi: 10.1007/s11709-023-0005-y

摘要： Soil conditioning is essential for addressing the stratum applicability problem of earth pressure balance (EPB) shields. Under high water pressures, EPB shields spew water and soil when excavating coarse-grained strata. Typically, foam combined with polymers and slurry is used to solve spewing. However, in current techniques, slurry, foam, and the other agents are mixed with soil separately, their synergistic effect is seldom realized. In this study, an anionic surfactant was used to foam in bentonite slurry to form bubble–slurry to maximize the synergy between bubbles and slurry. The slump, volume stability, and permeability test of bubble–slurry-conditioned sand was conducted to examine the conditioning effect, and the stratum applicability of bubble–slurry was determined from the perspective of permeability. It was found that the conditioning effect of bubble–slurry in coarse gravel soil was excellent and could expand the applicability of EPB shields. The main stabilization mechanism of bubble–slurry is that bentonite particles provide a space barrier for bubbles. And three seepage modes of bubble–slurry-conditioned sand were innovatively defined, and the occurrence conditions of the three seepage modes were analyzed according to the permeability coefficient of sand, initial dynamic shear force of bubble–slurry, and hydraulic gradient.

关键词： EPB shield bubble–slurry soil conditioning stability permeability

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大尺度地层内的分层运动

许绍燮

《中国工程科学》 2006年第8卷第6期页码 14-22

摘要：

报告了观察到大尺度地层内分层运动的新发现，以及大尺度层块活动的直接证据——大尺度地层垂向同步运动，其层块的尺度可大到数千公里洲际尺度。分析了我国超长周期（360～3000s）地震监测台站记录中的层块活动局域性高强颤振事件。发现格尔木台（2001年11月份）记录到的高强颤振事件与发生在其附近（2001.11.14）昆仑山口西M8.1大震有一定关系。这些信息对于探索地震预测，以及认识大地构造动力具有重要意义。

关键词：大尺度地层内的分层运动高强颤振事件地震预测

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富水砂卵石地层中大直径泥水盾构同步注浆技术

张长强,翟志国,陈明娟,金仲祥

《中国工程科学》 2010年第12卷第12期页码 75-78

摘要：

通过统计分析盾构掘进相关技术资料，综合考虑富水砂卵石地层中泥水盾构掘进参数、泥浆参数、盾构姿态、地层变形机理等信息，确定泥水盾构在砂卵石地层中掘进时，同步注浆主要技术参数间的经验公式，指导类似工程施工。

关键词：砂卵石地层泥水盾构同步注浆施工技术

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城市富水砂卵石地层大断面隧道浅埋暗挖工法研究

唐国荣,刘招伟,李建华

《中国工程科学》 2010年第12卷第12期页码 98-102

摘要：

针对北京富水砂卵石地层大断面隧道地层稳定性差、工程周边环境复杂、对沉降控制要求高等诸多难题，在大断面隧道中采用CRD法、洞桩法进行施工，有效控制了工程结构、沿线及周围建筑物和地下管线的变形，确保了工程及周围环境的安全。

关键词：砂卵石地层大断面 CRD法洞桩法隧道施工

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富水砂卵石地层盾构隧道施工泥浆的研究与应用

邓亨义,徐雪莹,陈明娟

《中国工程科学》 2010年第12卷第12期页码 79-82

摘要：

针对北京站至北京西站地下直径线工程泥水盾构施工，通过对泥浆性能研制的配比试验，提出了砂卵石条件下的最佳泥浆配比，提高并改善了泥浆的成形质量与速度，确保了环境要求。对类似工程有一定的借鉴作用。

关键词：泥水盾构砂卵石地层泥浆配合比

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大断面海底隧道软弱地层施工方法研究

黄明利,路威,徐恒国,谭忠盛

《中国工程科学》 2009年第11卷第7期页码 35-38

摘要：

我国第一条大断面海底隧道——厦门翔安海底隧道在浅滩及陆地段穿越富水软弱地层，围岩自稳能力差，极易发生涌水突泥，严重威胁施工的安全性。通过对隧道开挖方案的对比分析和根据施工现场监控量测的结果，对隧道穿越富水软弱地层的开挖施工方案、降排水关键技术和超前预加固方案进行了研究，为隧道施工提供技术支持。

关键词：厦门翔安海底隧道软弱地层施工方法

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大埋深富水砂卵石地层泥水盾构带压换刀及动火焊接技术

程明亮,何峰,吕传田

《中国工程科学》 2010年第12卷第12期页码 46-50

摘要：

通过北京铁路地下直径线工程盾构施工实践经验，总结了大埋深富水砂卵石地层泥水盾构施工中带压换刀技术以及特殊情况下的带压动火焊接技术。带压换刀的技术主要有两个方面:一是选择合理换刀地点及进舱工作压力，保证掌子面土体的稳定；二是进行开挖舱高浓度泥浆的置换和中盾高浓度泥浆的注入，有效地防止了气体的逃逸。在施工中成功实现了带压进舱250余次，工作压力从0.9 bar (1 bar=100 kPa)增加到2.8 bar，未发生任何安全事故。

关键词：泥水盾构砂卵石地层富水地层带压换刀焊接

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三维GIS中地层多比例尖灭自动建模技术

董志

《中国工程科学》 2010年第12卷第2期页码 76-82

摘要：

利用地质勘察数据导入到三维系统中，运用各种三维空间构模方法，自动进行地层推理与连接，生成三维地层模型。以多数据源自动生成模型，可以方便地使地学领域中的地质工作者从繁重的地质信息获取和地质解释手工劳动中解放出来，提高了三维地层建模的速度和构建质量。

关键词：地质三维模型虚拟钻孔多比例尖灭自动建模三角形自分解

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砂卵石条件下泥水分离技术研究与应用

王广余,孙善辉,苏清贵

《中国工程科学》 2010年第12卷第12期页码 41-45

摘要：

通过北京铁路北京站至北京西站地下直径线工程泥水处理系统的研究与应用实践经验，总结了城市繁华地段砂卵石条件下大直径盾构泥水分离应用技术，希望对类似工程有借鉴作用。

关键词：泥水盾构泥水分离压滤

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富水砂卵石地层大直径泥水盾构施工地表沉降规律

赵宝华,胡曦波,张兵,李文俊

《中国工程科学》 2010年第12卷第12期页码 94-97

摘要：

北京地下直径线工程位于富水砂卵石地层中，穿越诸多建（构）筑物。通过实际监测结果分析，总结掘进参数与地表沉降之间的规律及隧道周围重要建筑物的变形规律，经与类似工程比较后发现本工程在变形控制上有很大的成效。

关键词：富水砂卵石大直径泥水盾构沉降规律

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标题作者时间类型操作

Influence of short chain ceramides and lipophilic penetration enhancers on the nano-structure of stratumcorneum model membranes studied using neutron diffraction

Annett SCHROETER, Tanja ENGELBRECHT, Reinhard H. H. NEUBERT

期刊论文

Enhanced penetration strategies for transdermal delivery

Qiaofei Pan, Yinglin Yu, Dong Chen, Genlong Jiao, Xiaowen Liu

期刊论文

piles in the pile-caisson composite structure under eccentric inclined loading considering different stratum

期刊论文

Experimental study on the stratum applicability and mechanisms of bubble–slurry for earth pressure balance

期刊论文

大尺度地层内的分层运动

许绍燮

期刊论文